南京农业大学农业合成生物学中心依托前沿交叉研究院，面向世界科技前沿、国家重大需求和现代农业主战场，以合成生物学为核心引擎，融合农学、生物学、工程学与信息科学，推动农业研究与生产向可设计、可预测、可制造转变。
中心聚焦农业生物系统设计与合成原理、AI 赋能的使能技术平台、农业合成生物学应用与转化，构建从数据与模型、元件与底盘到绿色投入品和生物制造的“设计—构建—测试—学习”闭环。数字细胞与虚拟细胞研究结合机制模型与 AI 基础模型，在计算机中重建农业微生物和植物细胞，预测其对遗传和环境扰动的响应，并为实验设计提供依据。
The Center for Agricultural Synthetic Biology at Nanjing Agricultural University brings together agricultural science, biology, engineering and information science to make agricultural systems more designable, predictable and manufacturable.
Our work spans the design principles of agricultural biological systems, AI-enabled technology platforms, and application and translation—linking data and models, biological parts and chassis, and green biomanufacturing through a Design–Build–Test–Learn cycle. Digital and virtual cell research combines mechanistic models with AI foundation models to reconstruct agricultural microbes and plant cells in silico, predict their responses to genetic and environmental perturbations, and guide experimental design.
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融合机制驱动的基因组尺度模型与单细胞多组学基础模型，重建农业微生物和植物细胞，预测其对遗传、化学与环境扰动的响应。 Mechanistic genome-scale models and single-cell foundation models reconstruct agricultural microbes and plant cells and predict their responses to genetic, chemical and environmental perturbations.
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模拟蛋白从翻译、折叠到跨膜转运与分泌的全过程，预测宿主资源分配和异源蛋白产能。 Models of translation, folding, translocation and secretion predict host resource allocation and heterologous protein production.
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根际微生物组、共生固氮体系与作物细胞的数字孪生——把细胞模型与田间表型连起来。 Digital twins of the rhizosphere, nitrogen-fixing symbionts and crop cells — linking cellular models to field-scale phenotype.
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合成生物学元件库与数据库 (https://www.biosino.org/rdbsb/) Automated DBTL pipelines: part registries, circuit design, and model-guided experiment selection feeding back into the wet lab.
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已发布项目与规划仓库如下。 Published projects and planned repositories are listed below.
| Repository | 简介 · Description | Status |
|---|---|---|
Synbio Library |
合成生物学元件库与数据库 · Synthetic Biology Component Libraries and Databases |  |
yeast-aba-gem |
酿酒酵母合成脱落酸（ABA）的基因组尺度代谢模型 · Genome-scale metabolic model of ABA-producing Saccharomyces cerevisiae | |
salb-gem-pteridic-acid |
链霉菌 Pteridic acid 与 Elaiophylin 合成的代谢模型与通路工程 · Metabolic modelling and pathway engineering for pteridic acid and elaiophylin biosynthesis in Streptomyces albus |  |
virtual-cell-core |
全细胞模型仿真引擎 · Simulation engine for whole-cell models |  |
genome-scale-models |
农业微生物与作物的基因组尺度代谢模型库 · Curated GEMs of agricultural microbes & crops | |
cell-foundation-model |
单细胞基础模型与扰动预测 · Single-cell foundation model & perturbation prediction |  |
digital-rhizosphere |
作物根际微生物组数字孪生 · Digital twin of the crop rhizosphere microbiome |  |
syn-parts-registry |
标准化元件与线路库 · Standardized part & circuit registry | |
dbtl-pipeline |
DBTL 自动化流水线 · Automated Design–Build–Test–Learn workflows |  |
农业合成生物学中心
南京农业大学前沿交叉研究院
江苏省南京江北新区滨江大道666号
Center for Agricultural Synthetic Biology
Academy for Advanced Interdisciplinary Studies, Nanjing Agricultural University
No. 666 Binjiang Avenue, Jiangbei New Area, Nanjing, Jiangsu Province