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| 1 | +--- |
| 2 | +title: "IEMSB - Imaging Empowered Multiscale Biophysics (2026-2029)" |
| 3 | +summary: IEMSB brings together advanced imaging, artificial intelligence, chemistry and quantitative biophysics to connect molecular mechanisms with cellular and tissue function. |
| 4 | +date: 2026-01-01 |
| 5 | +end_date: 2029-12-31 |
| 6 | +funding: €649,000 |
| 7 | +funding_agency: "Gobierno Vasco - Ayudas para apoyar las actividades de grupos de investigación del sistema universitario vasco (2026-2029)" |
| 8 | +draft: false |
| 9 | +featured: true |
| 10 | +authors: ["Ignacio Arganda-Carreras", "Fadi Dornaika", "Nagore Barrena", "Unai Elordi", "Aitor González-Marfil"] |
| 11 | +image: |
| 12 | + filename: "euskal-jaurlaritza-logo.png" |
| 13 | + focal_point: "center" |
| 14 | + preview_only: true |
| 15 | +tags: |
| 16 | + - Multiscale Biophysics |
| 17 | + - Advanced Imaging |
| 18 | + - Artificial Intelligence |
| 19 | + - Bioimage Analysis |
| 20 | + - Fluorescence Microscopy |
| 21 | + - Cryo-Electron Microscopy |
| 22 | +--- |
| 23 | + |
| 24 | +The **Imaging Empowered Multiscale Biophysics (IEMSB)** initiative has been officially funded under the **Ayudas para apoyar las actividades de grupos de investigación del sistema universitario vasco (2026-2029)** programme. The final resolution was communicated on **24 August 2026**. |
| 25 | + |
| 26 | +Led by **Dr. Virginia Martinez-Martinez** and **Dr. Ignacio Arganda-Carreras**, IEMSB unites researchers from the University of the Basque Country (UPV/EHU) and the Spanish National Research Council (CSIC) at the Instituto Biofisika. The initiative connects molecular, cellular and tissue scales through advanced imaging, computation and quantitative biophysics. |
| 27 | + |
| 28 | +<figure> |
| 29 | + <img src="iemsb-figure.png" alt="IEMSB bridges cellular structure, tissue biophysics, AI-based imaging and chemistry through Basque imaging platforms" width="460"> |
| 30 | + <figcaption><b>Fig. 1:</b> IEMSB: Bridging scales through Imaging, Al, Chemistry and Biophysics. An initiative to foster scientific excellence, interdisciplinary training, and international impact.</figcaption> |
| 31 | +</figure> |
| 32 | + |
| 33 | +--- |
| 34 | + |
| 35 | +### 🔬 Scientific Goals |
| 36 | + |
| 37 | +IEMSB is organised around four complementary research lines: |
| 38 | + |
| 39 | +- **Structural Biology and Cellular Architecture**: resolving macromolecular structures and dynamics in native cellular environments using cryo-EM, cryo-ET and correlative fluorescence microscopy. |
| 40 | +- **Tissue Biophysics**: understanding how cell-ECM interactions, forces and adhesion dynamics shape neural and epithelial tissues during development, repair and ageing. |
| 41 | +- **AI-Based Tools for Imaging**: developing interpretable, scalable and data-efficient methods for denoising, segmentation, classification, particle picking and subtomogram analysis. |
| 42 | +- **Chemistry-Driven Tools for Imaging**: designing fluorophores, fluorogenic probes and biosensors for quantitative and super-resolution imaging of molecular events in living systems. |
| 43 | + |
| 44 | +The programme works in close coordination with the Basque imaging platforms **BRALM** (advanced light microscopy), **BREM** (electron microscopy) and **BRAIIAN** (AI and image analysis). Together, these platforms provide an integrated framework for imaging-driven multiscale biophysics. |
| 45 | + |
| 46 | +--- |
| 47 | +### 🌐 Basque Imaging Platforms |
| 48 | + |
| 49 | +- **BRALM**: advanced light and super-resolution microscopy. |
| 50 | +- **BREM**: cryo-electron microscopy, cryo-electron tomography and correlative imaging. |
| 51 | +- **BRAIIAN**: artificial intelligence, computer vision and image analysis. |
| 52 | + |
| 53 | +--- |
| 54 | +### 👥 Project Team |
| 55 | + |
| 56 | +#### Principal Investigators |
| 57 | + |
| 58 | +- Dr. **Virginia Martinez-Martinez** (Permanent Doctor Researcher, UPV/EHU) |
| 59 | +- Dr. **Ignacio Arganda-Carreras** (Ikerbasque Research Associate Professor, UPV/EHU; DIPC; Biofisika Institute) |
| 60 | + |
| 61 | +#### CVPD Team |
| 62 | + |
| 63 | +- Dr. **Fadi Dornaika** (Ikerbasque Research Professor, UPV/EHU) |
| 64 | +- Dr. **Nagore Barrena** (Assistant Professor, UPV/EHU) |
| 65 | +- Dr. **Unai Elordi** (Assistant Professor, UPV/EHU) |
| 66 | +- **Aitor González-Marfil** (PhD student, UPV/EHU; DIPC) |
| 67 | + |
| 68 | +The wider IEMSB group comprises 22 members, including 21 doctors and one predoctoral researcher, with expertise spanning physical chemistry, biochemistry, molecular biology, computer science and artificial intelligence. |
| 69 | + |
| 70 | +--- |
| 71 | +### 🕒 Timeline |
| 72 | + |
| 73 | +- **Start date**: 1 January 2026 |
| 74 | +- **End date**: 31 December 2029 |
| 75 | +- **Duration**: 48 months |
| 76 | + |
| 77 | +--- |
| 78 | +### 💰 Funding |
| 79 | + |
| 80 | +- **Call**: [Ayudas para apoyar las actividades de grupos de investigación del sistema universitario vasco (2026-2029)](https://www.euskadi.eus/ayuda_subvencion/2026/ikertalde/web01-tramite/es/) |
| 81 | +- **Funding body**: Gobierno Vasco / Euskal Jaurlaritza |
| 82 | +- **Resolution**: 24 August 2026 |
| 83 | +- **Granted total**: **649,000 €** |
| 84 | + |
| 85 | +<img src="euskal-jaurlaritza-logo.png" alt="Euskal Jaurlaritza - Gobierno Vasco" width="660"> |
| 86 | + |
| 87 | +--- |
| 88 | +### 📄 Project Documentation |
| 89 | + |
| 90 | +- [Official programme and call information](https://www.euskadi.eus/ayuda_subvencion/2026/ikertalde/web01-tramite/es/) |
| 91 | +- Final funding resolution communicated on **24 August 2026** |
| 92 | + |
| 93 | +--- |
| 94 | +### 📬 Contacts |
| 95 | + |
| 96 | +For project enquiries, please contact: |
| 97 | +- [Dr. Ignacio Arganda-Carreras](mailto:ignacio.arganda@ehu.eus) |
| 98 | +- [Dr. Virginia Martinez-Martinez](mailto:virgina.martinez@ehu.eus) |
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