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+---
+title: "First 3D map of the ovary across the reproductive lifespan"
+date: 2026-08-12
+authors: ["Daniel Franco-Barranco", "Ignacio Arganda-Carreras"]
+summary: "A Nature Aging study maps more than 85,000 oocytes in intact mouse ovaries and finds that the ovary maintains a fixed fraction of oocytes ready for activation throughout life."
+tags:
+  - Bioimage Analysis
+  - AI
+  - Microscopy
+  - BiaPy
+  - Reproductive Biology
+image:
+  focal_point: 'center'
+featured: false
+---
+
+We are pleased to announce the publication of **["Three-dimensional mapping of intact ovaries reveals the aging dynamics of the ovarian reserve"](/publication/dangelo-2026-three/)** in [*Nature Aging*](https://doi.org/10.1038/s43587-026-01178-z).
+
+<!--more-->
+
+In collaboration with researchers at the Centre for Genomic Regulation (CRG), EMBL Barcelona, DIPC, UPV/EHU and the Biofisika Institute, the study delivers the first complete three-dimensional map of the mouse ovary across its reproductive lifespan. The researchers combined whole-organ light-sheet microscopy, AI-based segmentation and mathematical modelling to identify and classify more than 85,000 oocytes in over 100 intact ovaries.
+
+The work shows that, even as the ovarian reserve declines markedly with age, the fraction of oocytes in the transition from dormancy to growth remains stable at around 14%. This finding suggests that the ovary actively regulates its reserve rather than acting as a passive store of egg cells. The study also reveals substantial variation in ovarian reserve between genetically identical mice, links local oocyte density to activation, and identifies a previously unrecognised bottleneck during oocyte growth.
+
+CVPD contributed to the AI-based image-segmentation workflow through **[BiaPy](https://biapyx.github.io/)**. The complete workflow, microscopy data and trained model have been openly released, enabling other researchers to reproduce the analysis and apply it to their own images.
+
+The findings establish a quantitative framework for studying ovarian aging. While the research was carried out in mice, the authors also demonstrated the method on human ovarian cortex tissue, opening a path towards future studies in humans.
+
+This work was supported by CVPD's [TOSBI](/project/tosbi-2025/), [AIM-Net](/project/aim-net-2025/) and [CALM4GRAINS](/project/calm4grains-2025/) projects, funded by the Spanish Ministry of Science, Innovation and Universities and the State Research Agency (MICIU/AEI).
+
+<img src="/assets/media/MICIU_Cofinanciado_AEI_logo.jpg" alt="Spanish Ministry of Science, Innovation and Universities and State Research Agency funding logos" width="500">
+
+Read more:
+
+- [Publication page](/publication/dangelo-2026-three/)
+- [Article in Nature Aging](https://doi.org/10.1038/s43587-026-01178-z)
+- [DIPC dissemination article](https://dipc.ehu.eus/en/whats-new/news/first-3d-map-of-ovary-throughout-reproductive-lifespan-reveals-it-counts-its-own-eggs?set_language=en)
+
+_Image credit: Arturo D'Angelo/CRG._