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| 1 | +--- |
| 2 | +title: "Robust Deep Learning for MRI-Based Alzheimer's Disease Detection: Overcoming |
| 3 | + Real-World Imaging Challenges" |
| 4 | +authors: |
| 5 | +- Mohamad Abou Ali |
| 6 | +- Mostafa Mohieldin |
| 7 | +- Fadi Dornaika |
| 8 | +- Ignacio Arganda-Carreras |
| 9 | +- Rejdi Chmouri |
| 10 | +- Ali Cherry |
| 11 | +- Ali Hage-Diab |
| 12 | +date: '2025-10-01' |
| 13 | +publishDate: '2026-04-13T10:35:42.258584Z' |
| 14 | +publication_types: |
| 15 | +- paper-conference |
| 16 | +publication: '*2025 Eighth International Conference on Advances in Biomedical Engineering |
| 17 | + (ICABME)*' |
| 18 | +doi: 10.1109/ICABME66883.2025.11211705 |
| 19 | +abstract: Detecting Alzheimer's disease (AD) from MRI scans remains a significant |
| 20 | + challenge in medical imaging due to the subtle, low-contrast anatomical changes |
| 21 | + associated with neurodegeneration. Real-world scans often suffer from noise, motion |
| 22 | + artifacts, and scanner variability, all of which can severely degrade deep learning |
| 23 | + (DL) model performance. In our previous work on MRI-based 4-class brain tumor classification, |
| 24 | + we developed a robustness methodology that employed Gaussian blur and Gaussian noise |
| 25 | + as augmentation techniques to counteract the impact of various image degradations-including |
| 26 | + multiple noise types, blurring methods, and simulated patient motion. In this study, |
| 27 | + we adapt and apply the same robustness strategy to a 4-class AD classification task |
| 28 | + using a publicly available Kaggle MRI dataset. To address class imbalance, we employed |
| 29 | + a Conditional Wasserstein GAN with Gradient Penalty (WGAN-GP) to generate a balanced |
| 30 | + training set of $mathbf2, 5 6 0$ images per class, while retaining the original, |
| 31 | + unaugmented test set. A fine-tuned EfficientNetV2B0 model achieved 99 % accuracy |
| 32 | + on the augmented training data; however, when evaluated under real-world challenges, |
| 33 | + performance dropped to $mathbf4 4. 3 3 %$-significantly lower than the 69.66 % achieved |
| 34 | + in the brain tumor benchmark. This stark contrast underscores the inherent difficulty |
| 35 | + of AD classification, exacerbated by low-resolution axial-only scans and minimal |
| 36 | + interclass visual differences. Although the robustness methodology yielded partial |
| 37 | + performance recovery, the results highlight the need for higher-resolution, multi-planar |
| 38 | + imaging and domain-specific preprocessing strategies. This study advances the understanding |
| 39 | + of robustness in DL-based neuroimaging and underscores the importance of tailored |
| 40 | + augmentation pipelines for reliable Alzheimer's diagnosis in clinical settings. |
| 41 | +tags: |
| 42 | +- Deep learning |
| 43 | +- Training |
| 44 | +- Visualization |
| 45 | +- Magnetic resonance imaging |
| 46 | +- Training data |
| 47 | +- Generative adversarial networks |
| 48 | +- Brain modeling |
| 49 | +- Robustness |
| 50 | +- Alzheimer's disease |
| 51 | +- Artificial intelligence |
| 52 | +- MRI Alzheimer Disease |
| 53 | +- MRI Brain Cancer |
| 54 | +- Deep Learning (DL) |
| 55 | +- Artificial Intelligence (AI) |
| 56 | +- Real-World simulation |
| 57 | +- Robustness |
| 58 | +- Generative Adversarial Networks (GAN) |
| 59 | +- Gaussian Augmentation |
| 60 | +links: |
| 61 | +- name: URL |
| 62 | + url: https://ieeexplore.ieee.org/abstract/document/11211705 |
| 63 | +--- |
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