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‎join.html‎

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@@ -361,7 +361,7 @@ <h3>Computational dissection of alternative splicing in neurodegeneration</h3>
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<!-- When no positions are open, keep this paragraph visible.
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Delete it when at least one .position-card is active above. -->
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<p class="no-positions">
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No positions are currently advertised. Please check back or get in touch speculatively — we are always happy to hear from exceptional candidates.
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No positions are currently advertised. Please check back, or get in touch speculatively; we are always happy to hear from exceptional candidates.
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</p>
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</div>
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</div>
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<p>
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We are particularly happy to support the application of very promising young scientists
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— with the quality, motivation, and ambition to become group leaders — to competitive
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(with the quality, motivation, and ambition to become group leaders) to competitive
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fellowship schemes. Funding sources we can support applications to include:
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</p>
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<ul>
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<li><a href="https://www.bifonds.de/fellowships-grants/phd-fellowships.html" target="_blank" rel="noopener">Boehringer Ingelheim Fonds PhD Fellowships</a> (international students)</li>
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</ul>
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<p>
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Please contact us <strong>well in advance</strong> of call deadlines — not when calls
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are already open — to allow time for the selection process and to build a competitive
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Please contact us <strong>well in advance</strong> of call deadlines, not when calls
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are already open, to allow time for the selection process and to build a competitive
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application together. We also consider co-supervision of PhDs in industry.
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</p>
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</div>
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<div class="join-cta">
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<p>
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Interested? We'd love to hear from you.<br>
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<strong>Send Nuno a brief introduction</strong> — include your research interests,
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<strong>Send Nuno a brief introduction:</strong> your research interests,
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CV, and two references.
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</p>
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<a href="mailto:nmorais@nms.unl.pt?subject=Lab%20application%20enquiry"

‎sections/research.html‎

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@@ -88,7 +88,7 @@ <h2 class="section-title fade-up">Research</h2>
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<div class="research-card-detail">
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<p class="research-card-desc">
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<em>CDKN2A</em> is a remarkable dual-coding locus encoding two structurally unrelated
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tumour suppressors — p16<sup>INK4A</sup> and p14<sup>ARF</sup> — through overlapping
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tumour suppressors (p16<sup>INK4A</sup> and p14<sup>ARF</sup>) through overlapping
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reading frames driven by distinct promoters. p16 inhibits CDK4/6 and is a well-established
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marker of cellular senescence; ARF stabilises p53 by restraining MDM2. Despite their
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centrality to cell cycle control, tumour suppression, and oncogene-induced senescence,
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<p class="research-card-desc">
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Identifying behavioural markers of disease risk associated with circadian disruption
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is challenging due to reproducibility concerns in under-powered human studies.
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Submarines provide an extreme model of circadian disruption — depriving crew of
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Submarines provide an extreme model of circadian disruption, depriving crew of
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natural light–dark cycles and limiting physical activity. We developed an effect
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size-based method to screen potential actigraphy-derived markers of the submarine
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environment, collecting data across pre-mission, mission, and post-mission periods.
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integrating circadian models from the Arcascope <em>circadian</em> package, it
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provides flexible preprocessing tools, support for multiple actigraphy file
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formats, standalone functions for commonly used actigraphy metrics, and
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implementations of several mathematical models of circadian rhythms — enabling
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implementations of several mathematical models of circadian rhythms, enabling
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users to move efficiently from raw wearable data to physiologically interpretable
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circadian outputs.
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</p>
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</div>
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<div class="research-card-detail">
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<p class="research-card-desc">
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Single-cell RNA sequencing (scRNA-seq) has revolutionised our understanding of
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cellular heterogeneity, yet the complexity of its analysis poses challenges for
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researchers without computational expertise. scStudio is a user-friendly,
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comprehensive, and modular web-based application designed to democratise
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scRNA-seq data analysis. It supports automated dataset retrieval from the Gene
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Expression Omnibus, user-uploaded datasets in a variety of formats, multi-dataset
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integration, and flexible parameter optimisation. The application covers all
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essential steps — quality control, normalisation, dimensionality reduction,
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clustering, differential expression, and functional enrichment analysis — and
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includes analysis history tracking, session export, and data sharing features.
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Single-cell RNA sequencing (scRNA-seq) has transformed our understanding of
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cellular heterogeneity, yet its analysis remains challenging for researchers
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without computational expertise. scStudio is a user-friendly, modular web-based
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application designed to democratise scRNA-seq data analysis. It supports automated
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dataset retrieval from the Gene Expression Omnibus, user-uploaded datasets in a
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variety of formats, multi-dataset integration, and flexible parameter optimisation.
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The application covers all essential steps: quality control, normalisation,
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dimensionality reduction, clustering, differential expression, and functional
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enrichment analysis, and includes analysis history tracking, session export, and
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data sharing features.
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scStudio is being applied to characterise immunosenescence at single-cell
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resolution.
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</p>

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