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Changelog

All notable release-facing changes to VascuQuest are recorded here.

Unreleased

Virtual Disease v1

  • Added the complete first-party Virtual Disease implementation chain: immutable disease requests, deterministic age-matched PWDB subject selection, healthy baseline reconstruction, causal disease physics, disease-aware full-network solving, and content-addressed in-memory PWDB-VD runtime populations.
  • Added four frozen mechanistic disease presets: carotid stenosis, iliac stenosis, fusiform abdominal aortic aneurysm, and large-artery stiffening.
  • Added runtime P, U, A, and Q materialisation at all 13 canonical common sites while preserving each selected PWDB canonical subject number under a separate disease dataset identity.
  • Added explicit DiseaseQuantityStatus handling so unsupported disease-state quantities cannot silently inherit healthy source values.
  • Added the public Python namespace vascuquest.disease, including generate_population(...) and explicit portable runtime-bundle export.
  • Added the vascuquest disease presets, disease describe, and disease generate command group.
  • Added explicit portable disease bundles containing result JSON documents, full provenance records, content checksums, request identity, quantity statuses, subject IDs, scientific warnings, and the current reconstruction qualification state.
  • Virtual Disease outputs remain MODELLED; the healthy reconstruction gate remains METRICS_ONLY_THRESHOLDS_NOT_FROZEN. No clinical-validation claim is made.

0.1.0 — 2026-08-26

First public research-software release candidate for the validated PWDB core scope.

Research capabilities

  • Canonical PWDB identity bound to Zenodo record 3275625.
  • Deterministic virtual-subject and cohort access across 4,374 simulation instances.
  • Canonical scalar quantities from verified PWDB source tables.
  • Subject-specific vascular geometry from the canonical geometry archive.
  • Common-site pressure (P), flow-velocity (U), luminal-area (A) and photoplethysmogram (PPG) waveforms.
  • Validated volumetric-flow reconstruction using Q = U*A, reported as RECONSTRUCTED evidence.
  • Structured evidence classes, provenance and strict reproduction semantics.
  • JSON and CSV export with scientific metadata preservation.
  • Shared Python API and command-line application services.
  • Explicit plugin contracts for backends, derivations, research operators, discovery methods and exporters.

Validation

The core PWDB scope passed real-source Tier-4 validation against the six canonical artifacts used by the release, including exhaustive subject alignment, complete geometry and common-site waveform inventories, representative public-API reads across source age groups, and real-source flow-rate reconstruction. The supported Python/platform package matrix also passed wheel/sdist build-install testing.

Scope boundary

Dense path-resolved PWDB waveform support is not part of VascuQuest 0.1.0. Its real-source ingestion was investigated separately, but no public path-resolved capability is claimed. VascuQuest 0.1.0 does not claim validation against the complete 44.3 GB PWDB archive.

Data and licensing

VascuQuest does not bundle, re-host or relicense PWDB. The software is Apache-2.0 licensed; upstream PWDB data remain external and retain their own source identity and citation requirements.