Wildfires and extracellular vesicles: Exosomal MicroRNAs as mediators of cross-tissue cardiopulmonary responses to biomass smoke

This code was generated to support the manuscript, 'Wildfires and extracellular vesicles: Exosomal MicroRNAs as mediators of cross-tissue cardiopulmonary responses to biomass smoke', published in Environment International in 2022.

Carberry CK, Koval LE, Payton A, Hartwell H, Ho Kim Y, Smith GJ, Reif DM, Jaspers I, Ian Gilmour M, Rager JE. Wildfires and extracellular vesicles: Exosomal microRNAs as mediators of cross-tissue cardiopulmonary responses to biomass smoke. Environ Int. 2022 Sep;167:107419. doi: 10.1016/j.envint.2022.107419. PMID: 35863239; PMCID: PMC9389917.

Experiment 1

• Determined the differentially expressed genes in mouse heart and lung tissue after exposure to varying biomasses (ie. Peat, Red Oak, Saline, Pine, or Eucalyptus) and durations (ie. 4 or 24 hours) using the DESeq2 package

Experiment 2

• Determined the differentially expressed miRNAs in mouse heart and lung tissue after exposure to varying biomasses (ie. Peat, Red Oak, Saline, Pine, or Eucalyptus) and durations (ie. 4 or 24 hours) using the DESeq2 package