3D Feature Viewer for UniProt

3D Feature Viewer for UniProt is a browser extension that brings structural protein interpretation directly into UniProt. It adds an interactive 3D workspace to UniProt entry pages so users can inspect post-translational modifications, variants, clinical annotations, precomputed variant-effect evidence, ligand context, and structural-context overlays without leaving UniProt.

Features

• View UniProt PTMs, disease-associated variants, ClinVar annotations, and AlphaMissense scores on available 3D structures.
• Switch between AlphaFold models and mapped experimental PDB structures.
• Per-residue predictor table: EVE, ESM1b, FoldX ΔΔG, conservation, and CADD scores via ProtVar.
• Ligand and pocket context: PDBe-KB known sites, AlphaFill ligand context, PubChem/ChEMBL chemical links, and structure-based pocket inspection.
• Open Targets tractability and drug evidence per protein.
• Ligand similarity by CACTVS/Tanimoto fingerprint against AlphaFill transplants.
• Export residue sets and annotation data to CSV.

Install

Chrome

Install from the Chrome Web Store

Firefox

Install from Mozilla Add-ons

Install manually from GitHub (latest build)

1. Go to the Releases page and download the latest release:
   • chrome-extension-v2.0.1.zip for Chrome
   • firefox-extension-v2.0.1.zip for Firefox
2. Unzip the downloaded file.

Chrome:

1. Open chrome://extensions/
2. Enable Developer mode (top-right toggle)
3. Click Load unpacked and select the unzipped folder

Firefox:

1. Open about:debugging#/runtime/this-firefox
2. Click Load Temporary Add-on
3. Select the manifest.json inside the unzipped folder

Firefox temporary add-ons are removed on browser restart.

Build from source:

git clone https://github.com/aminkvh/3D-Feature-Viewer-for-UniProt.git
cd 3D-Feature-Viewer-for-UniProt
pwsh ./build-all.ps1

Quick Start

1. Open any UniProt entry, e.g. https://www.uniprot.org/uniprotkb/P14867/entry
2. Go to a section with PTMs, variants, or related annotations.
3. Click View in 3D.
4. Choose a structure, filter annotations, click residues or the Nearby panel to inspect.
5. Export results via the Download menu.

Documentation

See the doc/ folder for a full guide to all features.

Data and Privacy

The extension runs entirely in the browser with no server-side component. It retrieves data from public resources (UniProt, PDBe, AlphaFold DB, 3D-Beacons, ProtVar, Open Targets, PubChem, AlphaFill). No personal data is collected. See PRIVACY_POLICY.md for details.

License

Released under the MIT License. See LICENSE.