diff --git a/binder/src/main/java/io/grpc/binder/internal/Outbound.java b/binder/src/main/java/io/grpc/binder/internal/Outbound.java
index 7db5bf0fbe4..330699f6d14 100644
--- a/binder/src/main/java/io/grpc/binder/internal/Outbound.java
+++ b/binder/src/main/java/io/grpc/binder/internal/Outbound.java
@@ -261,7 +261,9 @@ protected final void sendInternal() throws StatusException {
       transport.sendTransaction(callId, parcel);
       statsTraceContext.outboundWireSize(dataSize);
       statsTraceContext.outboundUncompressedSize(dataSize);
-    } catch (IOException e) {
+    } catch (IOException | RuntimeException e) {
+      // Checked IO failures and unchecked application serialization failures (for example
+      // Parcelable, metadata marshaller, or InputStream) both end the call. Do not catch Error.
       throw Status.INTERNAL.withCause(e).asException();
     }
   }
diff --git a/binder/src/test/java/io/grpc/binder/internal/RobolectricBinderTransportTest.java b/binder/src/test/java/io/grpc/binder/internal/RobolectricBinderTransportTest.java
index 63c47bf4f19..b5db7b72534 100644
--- a/binder/src/test/java/io/grpc/binder/internal/RobolectricBinderTransportTest.java
+++ b/binder/src/test/java/io/grpc/binder/internal/RobolectricBinderTransportTest.java
@@ -669,6 +669,31 @@ public void msgFragmentsDeliveredToClientOutOfOrder() throws Exception {
     assertThat(methodDescriptor.parseResponse(msg)).isEqualTo(largeMessage);
   }
 
+  @Test
+  public void uncheckedSerializationFailureClosesClientStream() throws Exception {
+    // Unchecked serialization failures must close the call, same as IOException.
+    server.start(serverListener);
+    client = newClientTransport(server);
+    startTransport(client, mockClientTransportListener);
+
+    RuntimeException failure = new IllegalStateException("serialization");
+    ClientStreamListenerBase listener = new ClientStreamListenerBase();
+    ClientStream stream =
+        client.newStream(methodDescriptor, new Metadata(), CallOptions.DEFAULT, noopTracers);
+    stream.start(listener);
+    stream.writeMessage(
+        new InputStream() {
+          @Override
+          public int read() {
+            throw failure;
+          }
+        });
+
+    Status status = listener.awaitClose(TIMEOUT_MS, MILLISECONDS);
+    assertAbout(status()).that(status).hasCode(Status.Code.INTERNAL);
+    assertThat(status.getCause()).isSameInstanceAs(failure);
+  }
+
   private static OneWayBinderProxy takeNextBinder(
       BlockingBinderDecorator<OneWayBinderProxy> decorator) throws InterruptedException {
     OneWayBinderProxy proxy = decorator.takeNextRequest(TIMEOUT_MS, MILLISECONDS);