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README.md

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Canonical notebook sequence

These 14 notebooks document the study workflow and aggregate analyses. Every committed notebook has no outputs, execution counts, attachments, patient data, or machine-specific paths.

Internal preprocessing independently centers P, C1, C2, and C3 crops and performs no explicit interphase registration. The corrected primary clinical/fusion analysis retains unresolved sex as missing and uses fold-local medians. The historical non-male-to-zero rule is sensitivity-only.

Create ignored configs/paths.yaml from configs/paths.example.yaml only when user-obtained data or authorized local artifacts are available. Patient-linked outputs must remain outside Git.

Order Notebook Classification
1 Internal cohort and splits Public dataset plus configured private storage
2 Independent-phase preprocessing and sex provenance Public dataset plus configured private storage
3 W3 single-phase CNN Historical workflow requiring private artifacts
4 W4 multiphase CNN Historical workflow requiring private artifacts
5 W5 radiomics-LightGBM Historical workflow requiring private artifacts
6 Late fusion and internal evaluation Public aggregate reanalysis; private artifacts required for refitting
7 External data acquisition Public acquisition into private storage
8 External DICOM-to-NIfTI Public dataset plus configured private storage
9 External tumor-mask preprocessing Public dataset plus operator-controlled private review
10 External mask-density QC Historical workflow requiring private images and masks
11 External liver-mask adapter Historical per-case method interface
12 External frozen inference Public aggregate reanalysis; complete historical CNN inference unavailable
13 Radiomics imputation controls Public aggregate reanalysis; private artifacts required for rerun
14 Explainability and aggregate figures Public aggregate figure generation; private artifacts required for case-level explainability

Boundaries

  • W3 fold 1 and W4 fold 0 checkpoints were not retained.
  • Source geometry, spacing, and phase-specific crop coordinates were not retained.
  • Public C2 crop-retention findings apply only to C2.
  • W5 is crop-restricted radiomics and its shape outputs are not verified physical-unit measures.
  • Exact full fusion contains W4 and W5 probability triplets, age, and sex; W3 is excluded.
  • External values are HCC sensitivities under model-defined unavailable-covariate scenarios.

See reproducibility and artifact contracts.