diff --git a/src/ontology/cl-edit.owl b/src/ontology/cl-edit.owl
index 528101f0a..afb686011 100644
--- a/src/ontology/cl-edit.owl
+++ b/src/ontology/cl-edit.owl
@@ -3368,6 +3368,7 @@ Declaration(Class(obo:CL_7770003))
 Declaration(Class(obo:CL_7770004))
 Declaration(Class(obo:CL_7770005))
 Declaration(Class(obo:CL_7770006))
+Declaration(Class(obo:CL_9900001))
 Declaration(Class(obo:CP_0000000))
 Declaration(Class(obo:CP_0000025))
 Declaration(Class(obo:CP_0000027))
@@ -36551,6 +36552,17 @@ SubClassOf(obo:CL_7770006 obo:CL_0002367)
 SubClassOf(obo:CL_7770006 ObjectSomeValuesFrom(obo:RO_0002162 obo:NCBITaxon_9606))
 SubClassOf(obo:CL_7770006 ObjectSomeValuesFrom(obo:RO_0002292 obo:PR_Q9UIK5))
 
+# Class: obo:CL_9900001 (crypt top colonocyte)
+
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:35530046") obo:IAO_0000115 obo:CL_9900001 "A mature, terminally differentiated colonic absorptive epithelial cell located at the top of the crypt (colonic surface epithelium), marked by high expression of AQP8 together with SLC26A3, CEACAM5, CEACAM7, GUCA2A, and TFF1. Represents the fully matured end-state of the colonocyte differentiation trajectory. Identified by sub-clustering analysis in the Human Gut Cell Atlas (HGCA) v1.")
+AnnotationAssertion(terms:creator obo:CL_9900001 "Claude")
+AnnotationAssertion(terms:date obo:CL_9900001 "2026-09-28T13:46:34Z"^^xsd:dateTime)
+AnnotationAssertion(obo:IAO_0000233 obo:CL_9900001 "https://github.com/obophenotype/cell-ontology/issues/3756")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:35530046") oboInOwl:hasRelatedSynonym obo:CL_9900001 "colonocytes late")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:35530046") oboInOwl:hasRelatedSynonym obo:CL_9900001 "surface colonocyte")
+AnnotationAssertion(rdfs:label obo:CL_9900001 "crypt top colonocyte")
+SubClassOf(obo:CL_9900001 obo:CL_1000347)
+
 # Class: obo:CP_0000000 (obsolete CP:0000000)
 
 AnnotationAssertion(obo:IAO_0100001 obo:CP_0000000 obo:CL_0017500)