From 42f0de4ac18a0396fdaf22c51dd1cde77b7f15b3 Mon Sep 17 00:00:00 2001 From: "claude[bot]" <41898282+claude[bot]@users.noreply.github.com> Date: Mon, 28 Sep 2026 13:51:15 +0000 Subject: [PATCH] Add new term: crypt top colonocyte (CL:9900001) Add a new term for crypt top colonocyte as requested in issue #3756. - Label: crypt top colonocyte - Parent: colonocyte (CL:1000347) - Definition sourced from PMID:35530046 as provided by the requester, describing the mature, terminally differentiated colonic absorptive epithelial cell at the top of the crypt (colonic surface epithelium), marked by high expression of AQP8 together with SLC26A3, CEACAM5, CEACAM7, GUCA2A, and TFF1. Identified by sub-clustering analysis in the Human Gut Cell Atlas (HGCA) v1. - Related synonyms: "colonocytes late", "surface colonocyte" - Uses a temporary CL:9900001 ID (from the idranges Temporary IDs range) to be replaced with a definitive ID by the standard reserialisation process (see recent commit df153e1). Signed-off-by: Claude Co-Authored-By: Claude Opus 4.7 --- src/ontology/cl-edit.owl | 12 ++++++++++++ 1 file changed, 12 insertions(+) diff --git a/src/ontology/cl-edit.owl b/src/ontology/cl-edit.owl index 528101f0a..afb686011 100644 --- a/src/ontology/cl-edit.owl +++ b/src/ontology/cl-edit.owl @@ -3368,6 +3368,7 @@ Declaration(Class(obo:CL_7770003)) Declaration(Class(obo:CL_7770004)) Declaration(Class(obo:CL_7770005)) Declaration(Class(obo:CL_7770006)) +Declaration(Class(obo:CL_9900001)) Declaration(Class(obo:CP_0000000)) Declaration(Class(obo:CP_0000025)) Declaration(Class(obo:CP_0000027)) @@ -36551,6 +36552,17 @@ SubClassOf(obo:CL_7770006 obo:CL_0002367) SubClassOf(obo:CL_7770006 ObjectSomeValuesFrom(obo:RO_0002162 obo:NCBITaxon_9606)) SubClassOf(obo:CL_7770006 ObjectSomeValuesFrom(obo:RO_0002292 obo:PR_Q9UIK5)) +# Class: obo:CL_9900001 (crypt top colonocyte) + +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:35530046") obo:IAO_0000115 obo:CL_9900001 "A mature, terminally differentiated colonic absorptive epithelial cell located at the top of the crypt (colonic surface epithelium), marked by high expression of AQP8 together with SLC26A3, CEACAM5, CEACAM7, GUCA2A, and TFF1. Represents the fully matured end-state of the colonocyte differentiation trajectory. Identified by sub-clustering analysis in the Human Gut Cell Atlas (HGCA) v1.") +AnnotationAssertion(terms:creator obo:CL_9900001 "Claude") +AnnotationAssertion(terms:date obo:CL_9900001 "2026-09-28T13:46:34Z"^^xsd:dateTime) +AnnotationAssertion(obo:IAO_0000233 obo:CL_9900001 "https://github.com/obophenotype/cell-ontology/issues/3756") +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:35530046") oboInOwl:hasRelatedSynonym obo:CL_9900001 "colonocytes late") +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:35530046") oboInOwl:hasRelatedSynonym obo:CL_9900001 "surface colonocyte") +AnnotationAssertion(rdfs:label obo:CL_9900001 "crypt top colonocyte") +SubClassOf(obo:CL_9900001 obo:CL_1000347) + # Class: obo:CP_0000000 (obsolete CP:0000000) AnnotationAssertion(obo:IAO_0100001 obo:CP_0000000 obo:CL_0017500)