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testing densification methods - #48

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Johnnyassaf wants to merge 5 commits into
mainfrom
seqr-loaded-loader
Open

Johnnyassaf wants to merge 5 commits into
mainfrom
seqr-loaded-loader

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@Johnnyassaf

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Purpose

  • Adds a standalone Hail Batch script (test_densify_chr1.py) that reads a densification checkpoint, filters to chr1, and runs two post-densification approaches
    side-by-side for comparison:
    • Current: adjust_vcf_types before sparse_split_multi (no info adjustment after)
    • Proposed: sparse_split_multi(filter_changed_loci) first, then adjust_info and adjust_vcf_types
  • Reports diagnostics for both (schema, row counts, variant drop accounting, LPL→PL downcode verification at multiallelic sites)

Proposed Changes

Checklist

  • Version Bump!
  • Related GitHub Issue created
  • Tests covering new change
  • Linting checks pass

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