diff --git a/news/+route-case-insensitive.bugfix.md b/news/+route-case-insensitive.bugfix.md
new file mode 100644
index 00000000000..13204c47085
--- /dev/null
+++ b/news/+route-case-insensitive.bugfix.md
@@ -0,0 +1 @@
+Match page routes case-insensitively on the backend, as React Router does on the frontend, so `on_load` events and `router.page.path` resolve for a URL like `/About` instead of falling back to the 404 page.
diff --git a/reflex/route.py b/reflex/route.py
index afd2c5fde94..2fa0ef3d635 100644
--- a/reflex/route.py
+++ b/reflex/route.py
@@ -180,7 +180,8 @@ def get_route_regex(keyworded_route: str) -> re.Pattern:
     # Join the regex parts and compile the regex
     regex_pattern = "".join(regex_parts)
     regex_pattern = f"^{regex_pattern}/?$"
-    return re.compile(regex_pattern)
+    # React Router matches route paths case-insensitively by default.
+    return re.compile(regex_pattern, re.IGNORECASE)
 
 
 def get_router(routes: list[str]) -> Callable[[str], str | None]:
diff --git a/tests/units/test_route.py b/tests/units/test_route.py
index 3e51a5b1bbe..a3c72a490d0 100644
--- a/tests/units/test_route.py
+++ b/tests/units/test_route.py
@@ -135,6 +135,23 @@ def test_get_router_splat_catchall(path: str, expected: str | None):
     assert router(path) == expected
 
 
+@pytest.mark.parametrize(
+    ("path", "expected"),
+    [
+        ("/About", "about"),
+        ("/ABOUT/", "about"),
+        ("/Posts/42", "posts/[id]"),
+        ("/team", "Team"),
+        ("/", "index"),
+    ],
+)
+def test_get_router_ignores_case(path: str, expected: str):
+    # React Router renders a page for any casing of its path, so the backend
+    # must resolve the same route to run its on_load events.
+    router = get_router(["index", "about", "posts/[id]", "Team"])
+    assert router(path) == expected
+
+
 @pytest.mark.parametrize(
     ("path", "expected"),
     [