live-output.txt

TIER3 PRIOR_FAILURE: NCT05165771 Sponsor decision to withdraw study.

tofacitinib / rheumatoid arthritis
compiled 6, not groundable 42, deferred 0

VERDICTS
  JAK1     -> STAT3    CONSISTENT    hops=1 paths=  1 C=1 R=0 llm=9
      JAK1 -> STAT3   −*+
      All 1 paths at 1 hop predict STAT3 down, as required.
  JAK3     -> STAT3    CONSISTENT    hops=1 paths=  1 C=1 R=0 llm=9
      JAK3 -> STAT3   −*+
      All 1 paths at 1 hop predict STAT3 down, as required.
  JAK1     -> TNF      CONTESTED     hops=2 paths=  4 C=3 R=1 llm=9
      JAK1 -> STAT3 -> TNF   −*+*+
      3 of 4 paths at 2 hops predict TNF down, 1 up.
  JAK3     -> TNF      CONSISTENT    hops=2 paths=  4 C=4 R=0 llm=9
      JAK3 -> STAT3 -> TNF   −*+*+
      All 4 paths at 2 hops predict TNF down, as required.
  JAK1     -> IL6      CONSISTENT    hops=2 paths=  3 C=3 R=0 llm=9
      JAK1 -> STAT3 -> IL6   −*+*+
      All 3 paths at 2 hops predict IL6 down, as required.
  JAK3     -> IL6      CONSISTENT    hops=2 paths=  4 C=4 R=0 llm=9
      JAK3 -> STAT3 -> IL6   −*+*+
      All 4 paths at 2 hops predict IL6 down, as required.

SPREAD {"CONSISTENT":5,"CONTESTED":1}

TIER4 sample: {"assayName":"Kinase selectivity panel","estimatedCostUSD":2400,"estimatedWeeks":3,"isMock":true}